Science

/science3527

Looking at the world as it is, unencumbered by how we want it to be. Proudly hosted by and co-modded by

This could be one of the biggest conceptual leaps that stems from AI

What happens if we replace the metaphor of DNA as a blueprint or a set of letters, to a full on generative model - like a variational autoencoder

The blueprint metaphor has got us this far. But now we need something with a much more flexible texture - that captures an expansive, emergent system which encodes endless possibilities.

https://osf.io/preprints/osf/r8z7c_v1
Great article on synthetic biology by @gmo

The industry feels like it's lost a lot of its lustre, but after reading this I feel a lot more hopeful about some of the amazing breakthroughs on the horizon and our potential "reconciliation with biology"
https://imagedelivery.net/BXluQx4ige9GuW0Ia56BHw/a8189b23-884b-4a42-54b5-7aa9bcdc1700/original
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Ayan
@gmo·3 days ago
Time for a Synbio Intervention (with love)

Take a deep dive with me and learn why “a cell is not a computer—a cell is a cell”

The bioengineering revolution isn’t dead. It’s just taking the long road.

https://open.substack.com/pub/editlife/p/synbios-reality-check
Latest drama out of the food science world:

Novo Nordisk announces project UPDATE to clarify the NOVA definitions of ultra-processed foods (a term coined by Brazilian professor Carlos Monteiro)

Monteiro sends back an open letter co-signed by 80+ scientists asking them to remove NOVA and UPFs from its title.

The food science world is now split into 2 camps, both arguing that the other position is anti-science.

https://x.com/NUPENS_USP/status/1894860514662203643

media.tenor.com
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Zahed🎩
@zahedtabnak.eth·5 days ago
Scientists have managed to turn light into a solid material. This is a revolution in quantum physics.
https://www.newsweek.com/supersolid-light-physics-quantum-mechanics-2041338
I love this article about a new definition of what math is: https://davidbessis.substack.com/p/weve-been-wrong-about-math-for-2300

It is interesting because it merges philosophy and neuroplasticity, coming up with a great solution that resonates with me.

It is interesting because, for me, math has been about imagination. (how could you possibly define the nth dimension without imagination?) But for others, apparently, that's something terrible, and it doesn't mix well with what math is about.


Pinging @july @cassie @eulerlagrange.eth for their thoughts about this topic.
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Daniel Lombraña
@teleyinex.eth·4 days ago
Math is a human mental activity based on playing the “Game of Truth”: when we do math, we make as if notions had precise definitions that were perfectly stable over time, as if statements had binary “truth” values, as if one could play Lego and deduce new true statements from existing ones.

We've been wrong about math for 2300 years

A radical conceptualist take on the foundations of mathematics

davidbessis.substack.com
Math is a human mental activity based on playing the “Game of Truth”: when we do math, we make as if notions had precise definitions that were perfectly stable over time, as if statements had binary “truth” values, as if one could play Lego and deduce new true statements from existing ones.
Scientists have genetically engineered mice with some key characteristics of an extinct animal that was far larger -- the woolly mammoth. This "woolly mouse" marks an important step toward achieving the researchers' ultimate goal -- bringing a woolly mammoth-like creature back from extinction, they say. "For us, it's an incredibly big deal," says Beth Shapiro, chief science officer at Colossal Biosciences, a Dallas company trying to resurrect the woolly mammoth and other extinct species.

https://science.slashdot.org/story/25/03/04/1624239/scientists-create-woolly-mice?utm_source=rss1.0moreanon&utm_medium=feed
Can’t believe 3b1b shorts didn’t make it here yet
Incredible breakthrough in next-gen DNA sequencing from Roche

At least 10x faster than current methods. High throughput. Cheaper reads. Game-changer for genomics

Great video explainer here:

https://youtu.be/G8ECt04qPos?si=2UWHc0ojQG_39-KK
I've seen a few viral posts recently pushing the link between race and traits like IQ

But as genomic research advances, it’s getting clearer that race is probably more of a social construct than a genetic reality

The real story is how outdated ideas keep trying to shape society when we have better ways to inform the stories we tell.

https://pioneerworks.org/broadcast/whats-real-about-race-rina-bliss
Quite excited about this out of MIT: a computer that fits into a single piece of thread weighing 5g!

Could be woven into clothing with all kinds of applications for bodily computing

Features analog sensing, digital memory, processing and communication

https://www.nature.com/articles/s41586-024-08568-6
/Science
Me going directly to the government after the federal research funding cuts
Taking DeSci to another level 👀…
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pugson
@pugson·20:47 25/02/2025
which one of you haters is trying to kill me this time
TIL Francis Crick's house has a golden double helix on it
🧬
https://imagedelivery.net/BXluQx4ige9GuW0Ia56BHw/a376a805-877e-40ac-07f4-a654ece90d00/original
Umm so we’re now turning our microscopes into 3D printers 💅🏽

Pre-print: https://www.biorxiv.org/content/10.1101/2025.02.20.639256v1
https://imagedelivery.net/BXluQx4ige9GuW0Ia56BHw/e8382796-3917-42ed-5af8-c2f829a6c700/original

Teach your microscope how to print: Low-cost and rapid-iteration microfabrication for biology

The application of traditional microfabrication techniques to biological research is hindered by their reliance on clean rooms, expensive or toxic materials, and slow iteration cycles. We present an accessible microfabrication workflow that addresses these challenges by integrating consumer 3D printing techniques and repurposing standard fluorescence microscopes equipped with DMDs for maskless photolithography. Our method achieves micrometer-scale precision across centimeter-sized areas without clean room infrastructure, using affordable and readily available consumables. We demonstrate the versatility of this approach through four biological applications: inducing cytoskeletal protrusions via 1 μm-resolution surface topographies; micropatterning to standardize cell and tissue morphology; fabricating multilayer microfluidic devices for confined cell migration studies; imprinting agar chambers for long-time tracking of C. elegans . Our protocol drastically reduces material costs compared to conventional methods and enables design-to-device turnaround within a day. By leveraging open-source microscope control software and existing lab equipment, our workflow lowers the entry barrier to microfabrication, enabling labs to prototype custom solutions for diverse experimental needs while maintaining compatibility with soft lithography and downstream biological assays. ### Competing Interest Statement The authors have declared no competing interest.

www.biorxiv.org
“Similarly, Darwin laid out the evolutionary theory of biological organisms with no idea whatsoever what the mechanism of heritability was. As Darwin proved, an evolutionary theory can go extremely far without knowledge of the specific mechanism of inheritance.” - Julian Gough
According to a recent paper by an Israeli research team, it is possible to SCIENTIFICALLY predict the likelihood of divorce. Would you like to try it? https://phys.org/news/2025-02-divorce-interactions-cultural-personal-values.html
https://imagedelivery.net/BXluQx4ige9GuW0Ia56BHw/84e753c8-2912-46ec-caf2-51f79f5e1100/original
if an ant hits you going 100000000 mph would you die or would it not matter
Sad everyone knows about all the rare and crazy physics in the universe but not the most critical force in your daily life
https://imagedelivery.net/BXluQx4ige9GuW0Ia56BHw/b69727ca-f048-41f9-6566-b63141585500/original
Without checking the internet, what's the left hand rule?
So many insane innovations coming at us fast

I haven’t even had a chance to do a deep dive into Microsoft’s quantum computing chip

What do you mean you found a topological superconductor

What do you mean there is no peer reviewed scientific paper

What

Do

You

Mean

Cc. The physicists @aviationdoctor.eth
In my opinion, the DeSci movement is largely made up of opportunistic business minds who tout decentralization but really just want to own a slice of the science pie sans offering any real innovation

However, in these strange times, a window for real change has opened—if they so dare 👀

https://idp.nature.com/authorize?response_type=cookie&client_id=grover&redirect_uri=https%3A%2F%2Fwww.nature.com%2Farticles%2Fd41586-025-00525-1%3FlinkId%3D13044544
Biological artificial intelligence on the horizon 👀
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Ayan
@gmo·22:00 18/02/2025
no longer building unicorn companies in /synbio we’ve moved on to literally engineering unicorns

This is not a drill!

This team plans to create artificial biological intelligence by 2030 🦄 🧬

possibly the end for us, but at least we’re going out weird

https://x.com/josiezayner/status/1891870475212496947
It looks like we can time travel backwards? 🤯

This paper recently published thinks that at quantum levels systems can go forward and backward, which is amazing.

"This discovery provided a mathematical foundation for the idea that time-reversal symmetry still holds in open quantum systems — suggesting that time's arrow may not be as fixed as we experience it... The research offers a fresh perspective on one of the biggest mysteries in physics. Understanding the true nature of time could have profound implications for quantum mechanics, cosmology and beyond."

https://www.nature.com/articles/s41598-025-87323-x
Recording an episode soon with the Molecule.xyz and Pump.science guys.

My first question: 'Is Desci a scam. Help me understand why not'.

What else would you guys like to ask?

(P.S.: Top 3 questions get a shout-out on the pod)
"a team at Oxford University describes using quantum teleportation to link two pieces of quantum hardware that were located about 2 meters apart, meaning they could easily have been in different rooms entirely. Once linked, the two pieces of hardware could be treated as a single quantum computer, allowing simple algorithms to be performed that involved operations on both sides of the 2-meter gap"

https://www.nature.com/articles/s41586-024-08404-x